A model diagram of MCT1-mediated lactate shuttle in skeletal muscle. Credit: Prof. Chen Yan’s group A research team led by Prof. Chen Yan and Prof. Yang Lifeng from the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences revealed a physiological function of monocarboxylate transporter 1 (MCT1) in mediating the intracellular and extracellular lactate transport in skeletal muscle. The team found that MCT1 regulates mitochondrial biogenesis of skeletal muscle and exercise activity, and the deletion of the MCT1 gene promotes the production of oxidative muscle fibers, enhances Read More