Research indicates lowering FIT positivity thresholds improves sensitivity, specificity comparable to mt-sRNA testing

Lowering the fecal immunochemical test (FIT) positive threshold yields levels of sensitivity and specificity that are comparable to those reported for multitarget stool RNA (mt-sRNA) testing without the additional testing, according to a research letter published June 1 in JAMA. Tobias Niedermaier, Ph.D., from the German Cancer Research Center in Heidelberg, and colleagues examined whether lowering the FIT positivity threshold could achieve levels of sensitivity and specificity comparable to mt-sRNA testing, which incorporates a commercially available FIT, concentration of eight RNA transcripts, and participant-reported smoking status, without additional stool testing Read More

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