Researchers map the effects of all potential changes in key cancer gene

Function scores capture fitness effects mediated at both the transcript and protein 457 level. Credit: Megan Buckley et al Researchers at the Francis Crick Institute have mapped all the possible outcomes of changes to a tumor-suppressing gene called VHL, the first step in a huge research endeavor to unpick the outcomes of tens of thousands of genetic variations in genes associated with cancer. This VHL map could help clinicians work out which patients are at risk of developing kidney cancer or might respond to certain drugs. Genetic changes or variants Read More

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