Metabolic seahorse assays revealed alterations in glycolysis function and oxidative phosphorylation in the presence of the PAX4 p.Arg192His or p.Tyr186X variants. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-41860-z It was earlier discovered that a variation in the PAX4 gene specifically predisposes East Asians to a higher risk of developing type 2 diabetes (T2D), increasing lifetime risk by up to 1.8 times. A new study, now published in the journal Nature Communications, reveals for the first time how an East Asian-specific PAX4 gene variant, R192H, impacts the development and function of beta Read More