Month: June 2016

The endothelial cell lines the internal lumen of all the vasculatures and serves as an interface between circulating blood and vascular smooth muscle cells [1]. Endothelium serves as a physical barrier between the blood and tissues. Morover, it is able to respond to chemical and physical signals by production of a wide range of factors that regulate vascular tone, cellular adhesion, smooth muscle cell proliferation, and vessel wall inflammation [2]. Endothelial dysfunction has been reported

Allergic rhinitis (AR) is a symptomatic nasal disorder resulting from an IgE-mediated immunological reaction to allergen exposure [1]. AR is a worldwide health problem affecting people of all ages. The reported incidence of AR is 11.8–46 % worldwide [2, 3] and 11.1–19.1 % in China [4, 5]. AR is classified into intermittent allergic rhinitis (IAR) and persistent allergic rhinitis (PAR) according to the time of exposure. The major symptoms of AR include rhinorrhea, nasal itching, nasal obstruction,

Received: 20 June 2016 Accepted: 20 June 2016 Published: 30 June 2016

Both the characteristics of physical and social affordances are factors influencing the level of physical activity. The findings reveal differences in the physical activity levels of children in a natural environment (level 4.4), compared to outdoor play space in the kindergarten (level 3.1). One explanation is that walking to and returning from trip destinations in a natural environment are physically demanding for many children (levels 3 or 4). Taking walks may encourage children who are

It has been reported that HCAs are most common in women who have taken oral contraceptives for long periods of time (Baum et al. 1973). The male-to-female ratio is 1:9, which is lower than that in our study (1:1). Our data coincide with reports from Asia (Kong et al. 2015; Hung et al. 2001) that suggested that a lower use of oral contraceptives in women and routine screening for hepatocellular carcinoma in men may result

/ no comments Archaeologists have discovered a tunnel dug by Jews to escape the Nazis in Lithuania — a sign of resistance in a land where 90 percent of the Jewish population perished during the Holocaust.

15-year-old came to hospital complaining of nausea and pain in her side Doctors suspected appendicitis and operated to remove her appendix They discovered a ‘multitude’ of long white worms wriggling on the organ She had pinworms, the most common type of intestinal worm infection By Madlen Davies for MailOnline Published: 16:30 EST, 30 June 2016 | Updated: 16:48 EST, 30 June 2016 2 View comments Long, white and furiously wriggling, this video shows a teenager’s

When trying for a baby, it is widely accepted that prospective mothers should quit smoking. But, now a new study adds weight to the evidence in favor of advising fathers to stub out their habit as well. A team of Brazilian researchers found smoking damages a man’s sperm, in such a way that can make fertilization of his partner’s egg impossible.  Past research has shown that tobacco is linked to a decrease in sperm concentration

Pensioner developed sepsis thought to be from cavities in dog’s mouth Paramedics found her slumped in a chair after relative alerted them She had suffered multiple organ failure caused by blood poisoning sepsis Doctors said case was unusual as she had not been bitten or scratched  Patient was discharged after treatment with antiobiotics 30 days later By Rosie Taylor for the Daily Mail Published: 16:30 EST, 30 June 2016 | Updated: 16:30 EST, 30 June

College students who use e-cigarettes are more likely to smoke cigarettes New study links devices to greater risk of alcohol use, experts say Also found male college students are more likely to use the devices  By Lizzie Parry For Dailymail.com Published: 14:01 EST, 30 June 2016 | Updated: 14:01 EST, 30 June 2016 13 View comments The debate is complex, and provokes strong opinions on both sides of the scientific fence. In one camp are

Paul Gilbert. Credit: University of Iowa In the late 1980s, researchers across the United States began reporting a link between discrimination against African Americans and poor cardiovascular health within the African American population. Eventually, the scope of these studies broadened, uncovering a connection between discrimination and other health disparities among minority groups. Now, researchers at the University of Iowa have found another negative health outcome linked to discrimination: alcohol abuse. “We’ve had this idea that

For the majority of patients with large or difficult to remove colorectal polyps (growths in the colon), the incidence of cancer is actually lower than previously thought, and using more advanced endoscopic techniques that spare the colon may be a better, safer alternative to a traditional operation in certain cases, according to study results published online in the Journal of the American College of Surgeons in advance of print publication. The screening for and removal

Falling up to six months before an elective surgery was common and caused injuries among all adults, according to research from Washington University School of Medicine in St. Louis. The study suggests that falling may be an important indicator of baseline health. Credit: Washington University in St. Louis In a large study of 15,000 adults undergoing elective surgery, researchers at Washington University School of Medicine in St. Louis found that falling up to six months

(HealthDay)—For patients with nasal valve insufficiency, functional and aesthetic-functional rhinoplasty, involving reconstruction of the lateral nasal wall achieved with use of spreader and alar grafts, are associated …

Radix Astragali, A widely used Chinese Herbal Medicine, is derived from the dried roots of Astragalus mongholicus (Fisch.) Bge. (Zu et al. 2009). A. mongholicus generally is mixed with other ingredients to make some medicated food in its edible aspect, which it has also traditionally been utilized in cosmetics. Pharmacological studies and clinical practice have demonstrated that A. mongholicus possess various biological activities including tonic, immunostimulant, hepatoprotective, diuretic, antidiabetic, cardioprotective, anti-oxidative and anti-tumor properties (Sun

Synucleinopathies comprise a group of neurodegenerative diseases characterized by abnormal deposition of ?-synuclein in neurons and glia. The most frequent synucleinopathy is Parkinson’s disease (PD), in which ?-synuclein pathology propagates throughout the brain as clinical symptoms progress [1]. Possible pathological mechanisms resulting in ?-synuclein aggregation and neurodegeneration in sporadic PD are environmental factors, mitochondrial dysfunction, oxidative stress, and neuroinflammation [2, 3]; however, the exact mechanism of ?-synuclein aggregation remains elusive. Myeloid cells collectively describe cells

Received: 22 January 2016 Accepted: 21 June 2016 Published: 30 June 2016

The complex pattern of posttranslational modifications (PTMs) of histone proteins result in an epigenetic regulatory code that controls entire gene expression programs within a cell [1]. One of the best characterized histone modifications is methylation, that can occur on lysine or arginine residues [2]. Lysine methylation is mediated by histone lysine methyltransferases (HKMTs), a protein family defined by the presence of the SET domain, named after the Drosophila proteins Suppressor of variegation 3–9 [Su(var)3–9], Enhancer

Annually, just the global feather waste from the poultry processing industry reaches 8.5 million tons. At present, the poultry feathers are dumped, buried, used for land filling, or incinerated, resulting in environmental challenges in terms of storage, handling, emission control, and ash disposal (Agrahari and Wadhwa 2010). Poultry feathers are also turned into feather meal used as animal feed because of the high protein content. However, the use of waste for animal feed is becoming

i Frigatebirds have to find ways to stay aloft because they can’t land on the water. This bird was flying between the Galapagos islands of Santiago and Bartolome. Harvey Barrison/Flickr Frigatebirds, seagoing fliers with a 6-foot wingspan, can stay aloft for weeks at a time, a new study has found. The results paint an astonishing picture of the bird’s life, much of which is spent soaring inside the clouds. Frigatebirds are unique among aquatic birds.

Very long chain (VLC)-PUFA synthesis in M. alpina proceeds predominantly through the FADS6 pathway, in which the first committed step is the delta-6 desaturation (Additional file 1: Fig. S1), and FADS6 is generally considered to be a rate-limiting enzyme for this pathway [15, 16]. The substrate preference of FADS6 determines whether LA can be further converted to ?6-PUFAs or ALA to ?3-PUFAs. Our previous study showed that MaFADS6-I had substrate preference for LA and not

Daratumumab in combination regimens The enhanced anti-myeloma activity of daratumumab in combination with other agents in preclinical trials provided rationale for investigation of daratumumab in combination regimens. Daratumumab in combination with lenalidomide and dexamethasone in patients with relapsed or relapsed and refractory myeloma is being studied in an ongoing, phase 1/2, open-label, multicenter trial [29]. In part 1, a 3?+?3 design dose-escalation study, daratumumab was administered at doses of 2 to 16 mg/kg in combination with

The primary objective of this study was to determine the safety and tolerability of the combination of the GR steroidal antagonist mifepristone and nab-paclitaxel. We also sought to confirm that systemic GR antagonism was occurring with the mifepristone dose used in this trial. Dose-limiting neutropenia (as specified in the protocol) was observed at both doses of nab-paclitaxel; therefore, we halted the study and analyzed the pharmacokinetic data for a potential drug–drug interaction. The novel randomized

i Frigatebirds have to find ways to stay aloft because they can’t land on the water. This bird was flying between the Galapagos islands of Santiago and Bartolome. Harvey Barrison/Flickr A new study has found that frigatebirds, sea-going flyers with a 6-foot wingspan, can stay aloft for months at a time. The results paint an astonishing picture of the bird’s life, much of which is spent soaring among the clouds. Frigatebirds are unique among aquatic

i Women from a traditional sea-harvesting community fish in Mozambique. Michael D. Kock/Nature hide caption toggle caption Michael D. Kock/Nature Women from a traditional sea-harvesting community fish in Mozambique. Michael D. Kock/Nature There are many important reasons to manage the world’s wild fisheries. We do it to maintain stock levels, to ensure biodiversity and because fish are valuable. But researchers say there’s something else in need of protection: The very people who rely on fish

/ no comments University of Alabama at Birmingham

For the majority of patients with large or difficult to remove colorectal polyps (growths in the colon), the incidence of cancer is actually lower than previously thought, and using more advanced endoscopic techniques that spare the colon may be a better, safer alternative to a traditional operation in certain cases, according to study results published online in the Journal of the American College of Surgeons in advance of print publication. The screening for and removal

Can a computer game train your brain to resist sweets? That’s the question Drexel University researchers hope to answer with one of two new studies launching this month. They have developed a computer game and smartphone app to help people control unhealthy eating habits and ultimately lose weight. The game is designed to improve a person’s “inhibitory control,” the part of the brain that stops you from giving into unhealthy cravings — even when the

An experimental vaccine against Zika virus developed by Brazilian and US researchers has been tested successfully in trials with mice. The results were published on June 28, 2016 in Nature and according to the authors suggest a vaccine can be produced for humans in the near future. In Brazil the trials were performed under the aegis of the Zika Virus Research Network in São Paulo (Rede Zika), with FAPESP’s support, and coordinated by Jean Pierre

Phase III trial confirms efficacy and safety of new second-line agent Oral multikinase inhibitor regorafenib achieves significantly improved survival rates compared to placebo in patients with hepatocellular carcinoma, according to data from the phase III RESORCE trial, presented at the ESMO 18th World Congress of Gastrointestinal Cancer in Barcelona, Spain. “Systemic treatment for hepatocellular carcinoma has long consisted of just one agent – sorafenib -which was shown to provide a significant improvement in life expectancy

Girlfriend of man refused to sleep without him when he was in hospital She ‘march through that hospital policy with a blanket and a pillow’ A photo of them sleeping was posted by the man on Reddit He also shared a photo of his son teaching him how to walk again A year and a half later he completed an 11 mile endurance race  By Lauren Ingram For Daily Mail Australia Published: 01:14 EST, 30

After two months away from her boyfriend, Jo Asker was determined their reunion was going to be a romantic occasion. They flew to Malibu where their long-anticipated night started with a twilight stroll on the beach, followed by cocktails and dinner at one of the area’s most exclusive restaurants. After a magical evening of food, conversation and long, lingering glances, Jo, a 46-year-old book editor from West London, and Peter retired to their hotel room

Makeup blogger Habiba has used banana peel to get rid of acne  She uploaded a video showing the technique to her Instagram account It works because of properties in the peel that reduce inflammation The blogger has more than 28,000 followers on Instagram  By Lauren Ingram For Daily Mail Australia Published: 17:54 EST, 29 June 2016 | Updated: 18:13 EST, 29 June 2016 99 View comments One beauty blogger has uploaded a video claiming you can

Chantele Nielsen, 13, was vaccinated against cervical cancer in April Since, her mother claims she faints up to 8 times a day or falls asleep Now needs a wheelchair in case she collapses and injures herself Mother urges parents to find out more before vaccinating daughters By Anna Hodgekiss for MailOnline Published: 04:29 EST, 29 June 2016 | Updated: 07:04 EST, 29 June 2016 49 View comments Chantele Nielsen has been left wheelchair-bound, suffering from

Researchers at Cardiff University have found that online information about ovarian cancer can cause as much worry as comfort for women at high risk of developing the disease, in a new study published in ecancer. For women at an increased risk of ovarian cancer but who haven’t yet developed the disease, the most effective way to manage their risk is to surgically remove their fallopian tubes and ovaries. However when interviewed, the women faced with

The nerve cells that transmit pain signals in the body are called nociceptors. When activated they release pro-inflammatory neuropeptides. In order to recognise harmful external influences, nociceptors are equipped with a wide range of receptors. The capsaicin receptor channel, for example, reacts strongly to the spicy substance in chili peppers. Another receptor is sometimes called the mustard oil receptor as it is activated by a substance found in mustard, horseradish and onions. This receptor, whose

Biofilms are communities of bacteria that adhere to a surface and are nearly impossible to eradicate when they are pathogenic, or disease-causing. Fortunately, a discovery from the laboratories of Lauren Bakaletz, PhD, and Steven Goodman, PhD, in The Research Institute at Nationwide Children’s Hospital, provides strong evidence that an innovative therapeutic approach may be effective in the resolution of bacterial biofilm diseases. “Most, if not all, chronic and recurrent bacterial infections include a biofilm in

/ no comments Lund University

While there are a number of studies on alcohol misuse, most of the research has been focused on the adult population. Alcohol is the most widely used drug among young adults between the ages of 18 to 25. Binge drinking — almost a rite of passage — peaks during the college years. So this begs the question, “Are there specific characteristics associated with high-level binge drinking habits in college students?” A new psychology study conducted

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Rory was born weighing 12lb 7oz, twice the size of most newborns He was conceived though IVF and born after a five hour labour Charlotte Hawthorn, 23, and Mathew Williams, 26, had no idea he’d be so big By Kelly Strange for MailOnline Published: 06:43 EST, 30 June 2016 | Updated: 08:50 EST, 30 June 2016 13 View comments A proud mother has described the eye-watering moment she gave birth to one of Britain’s biggest

As Marcus Williams bowed out of Wimbledon following his fairytale clash with Roger Federer yesterday, the rank outsider proudly declared he had ‘earned a beer’. The world number 722 managed to win seven games which is no mean feat against the seven times champ – and must have left him physically exhausted. A dream day for the 25-year-old tennis coach, few would blame him for wanting to raise a glass or two to celebrate a memorable

Medical blunder took place during keyhole surgery on an unnamed patient One surgical team went for a tea break and another team took over Equipment called endoractor left behind before second op to remove it  NHS Lanarkshire says it now recommends avoiding unnecessary staff changeover during surgery By Kate Pickles For Mailonline Published: 06:48 EST, 30 June 2016 | Updated: 08:06 EST, 30 June 2016 51 View comments Bungling NHS staff left a sponge inside

They’re something we all yearn for but washboard abs are also something many of us struggle to achieve. We all know that ditching carbs and alcohol can help shift the weight around our middle but did you know there’s plenty of other reasons you may be struggling to get a flat stomach that don’t have anything to do with the food that passes your lips?  From chewing gum to having bad gut bacteria, Dr Marilyn

/ no comments Max Planck Institute for Psycholinguistics

Researchers from the Institute for Stem Cell Research and Regenerative Medicine at the University Clinic of Düsseldorf have established an in vitro model system for investigating nonalcoholic fatty liver disease (NAFLD). The study led by Prof. James Adjaye has now been published in the journal Stem Cells and Development. Nonalcoholic fatty liver disease (NAFLD), also called steatosis, is a dramatically under-estimated liver disease, with increasing incidences throughout the world. It is frequently associated with obesity

Butter consumption was only weakly associated with total mortality, not associated with cardiovascular disease, and slightly inversely associated (protective) with diabetes, according to a new epidemiological study which analyzed the association of butter consumption with chronic disease and all-cause mortality. This systematic review and meta-analysis, published in PLOS ONE, was led by Tufts scientists including Laura Pimpin, Ph.D., former postdoctoral fellow at the Friedman School of Nutrition Science and Policy at Tufts in Boston, and

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Created by a multidisciplinary team at the UPV/EHU-University of the Basque Country, it analyses 40,000 proteins per minute Biology and computing have joined forces to create a piece of software that analyses mutations in proteins; these mutations are potential inducers of diseases, such as cancer. The geneticists Asier Fullaondo and José Antonio Rodríguez, and the telecommunications engineer Gorka Prieto have created WREGEX 2.0, a free, easy, versatile and, above all, fast bioinformatics application that is

Article from Environment International wins Elsevier’s Atlas Award It is time we act proactively to minimize the effect of climate change on our health, say the researchers behind a new review published in Environment International. To do this, more cross-disciplinary collaboration is needed to predict how climate change will alter the outbreak and spread of infectious diseases. The review, carried out by researchers from Texas State University, USA and Tsinghua University, China, won Elsevier’s Atlas

WARNING, GRAPHIC CONTENT  Mexican man is seen lying on his back with a red and inflamed tattoo Another man pulls stringy bits of cyst out of a wound with nail clippers Once the ‘plug’ is removed a never-ending river of brown pus flows out Fluid is mopped up with a towel which soon becomes completely soaked By Madlen Davies for MailOnline Published: 06:54 EST, 30 June 2016 | Updated: 06:59 EST, 30 June 2016 1

Medical blunder took place during keyhole surgery on an unnamed patient One surgical team went for a tea break and another team took over Equipment called endoractor left behind before second op to remove it  NHS Lanarkshire says it now recommends avoiding unnecessary staff changeover during surgery By Kate Pickles For Mailonline Published: 06:48 EST, 30 June 2016 | Updated: 06:51 EST, 30 June 2016 2 View comments Bungling NHS staff left a sponge inside

They’re something we all yearn for but washboard abs are also something many of us struggle to achieve. We all know that ditching carbs and alcohol can help shift the weight around our middle but did you know there’s plenty of other reasons you may be struggling to get a flat stomach that don’t have anything to do with the food that passes your lips?  From chewing gum to having bad gut bacteria, Dr Marilyn

Joey Bottrill, almost 2, would wake up 10 times a night itching and in pain His bedsheets were covered in blood despite wearing protective bandages  Strangers in the street thought injuries were from falling over or fighting His mother read about a remedy which have helped to ease his symptoms By Kate Pickles For Mailonline Published: 05:25 EST, 30 June 2016 | Updated: 05:53 EST, 30 June 2016 1 View comments A toddler whose eczema was

A bride-to-be who bravely posted pictures of her scars after battling skin cancer was told she was making it up for attention by cruel trolls. Gemma Cottam, was left with a horseshoe scar from her ear to her chin after battling stage three melanoma – and posted pictures to encourage women to stay off sunbeds and wear sun cream.  The 25-year-old was left devastated when cruel trolls bombarded her Facebook campaigning page – Mela-no-more –

/ no comments American Chemical Society

The targeted therapy everolimus may be safely combined with R-CHOP for new, untreated diffuse large B-cell lymphoma according to the results of a pilot study by Mayo Clinic researchers published in the Lancet Haematology. R-CHOP is a combination of drugs used to treat lymphoma. The combination includes rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone. “There is an unmet need to develop new therapies based on R-CHOP to try to increase the cure rate for diffuse large

/ no comments Institute of Molecular Biotechnology

You might not want to depend on your smartphone app alone to help you avoid or achieve pregnancy, say the authors of a new study. A review of nearly 100 fertility awareness apps finds that most don’t employ evidence-based methodology. The findings, published in the Journal of the American Board of Family Medicine, also found that many apps include a disclaimer discouraging use for avoiding pregnancy. The study was led by Marguerite Duane, MD, MHA,

Men who sleep either fewer or more hours than average may face a greater risk of developing diabetes, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology Metabolism. More than 29 million people nationwide have diabetes, according to the Endocrine Society’s Endocrine Facts and Figures Report. During the last 50 years, the average self-reported sleep duration for individuals has decreased by 1.5 to 2 hours, according to the study’s senior

Many healthy eaters would consider grabbing a sandwich for lunch or tucking into a pasta at dinner time, the ultimate dietary sin. As the Paleo diet has picked up in popularity where the Atkins left off, the common wisdom among the nutritionally conscious is that being carb-free equates to staying trim.  And the nation’s carbophobia is not just theoretical. Last year, sales for Britain’s top three bread brands, Warburtons, Hovis and Kingsmill, were down a total

A London mother-of-two has revealed how an extreme weight loss routine using leech therapy helped her lose a staggering nine stone, taking her from a size 28 to a slim 12 to 14. Alex Bogatyriova, who lovingly cares for her ‘pets’ in her own home, insists that leech therapy has improved her sex life helping her deal with peri menopausal symptoms and improving her orgasms. ‘They are the secret to my weight loss and I

Zika is linked to microcephaly – where babies have small brains and heads But a fifth of infected infants had normal head sizes, scientists found Medics should check for signs of brain abnormalities as well as head size  By Madlen Davies for MailOnline Published: 02:04 EST, 30 June 2016 | Updated: 02:31 EST, 30 June 2016 2 View comments Babies with brains damaged by Zika may appear normal, scientists warn. Zika has been linked to

So here’s the bottom line. If you’re suffering from dodgy knees, clicky hips or a touch of backache, the culprit may not be staring you in the face, because it’s actually right behind you – a lazy, under-used derriere. An increasingly sedentary lifestyle is being blamed for a condition dubbed Dormant Bottom Syndrome (DBS) by one American medic. It’s becoming a more and more prevalent problem due to the amount of time we all spend

Nerves in the central nervous system of adult mammals do not usually regenerate when injured. The granule cell, a nerve cell located in the cerebellum, is different. When its fibres, called parallel fibres, are cut, rapid regeneration ensues and junctions with other neurons called “synapses” are rebuilt. The precise mechanism for this was unclear. Researchers at Hokkaido University in Japan, together with colleagues from Sapporo Medical University School of Medicine and Niigata University, investigated the

A new microscopy technique (LM-method) developed to detect Lyme disease is unable to distinguish infected patients from healthy controls, yielding false-positive results that could lead doctors to over-diagnose a patient, according to new research published in the journal Infectious Diseases. The new research follows up on a previous study suggesting that modified microscopy techniques (LM-method) could detect active cases of Lyme disease (caused by Borrelia bacteria) and Babesia (a tick-borne malaria-like parasite) in just one

Research groups led by Professor Kohji Nishida of the Department of Ophthalmology and Endowed Associate Professor Ryuhei Hayashi of the Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine, developed a 2D culture system which mimics the development of the whole eye by promoting cell-autonomous differentiation of human iPS cells. While studies in the past only described techniques to generate the posterior portion of the eye (the retina, the pigmented epithelium

Vision loss due to glaucoma or optic nerve damage is generally considered irreversible. Now a new prospective, randomized, multi-center clinical trial demonstrates significant vision improvement in partially blind patients after 10 days of noninvasive, transorbital alternating current stimulation (ACS). In addition to activation of their residual vision, patients also experienced improvement in vision-related quality of life such as acuity, reading, mobility or orientation. The results are reported in PLOS ONE. “ACS treatment is a safe

/ no comments Journal of Occupational and Environmental Medicine

/ no comments Baylor Scott White Health