Month: May 2015

Using high-precision genetic tests to differentiate the thousands of bacteria that make up the human microbiome, researchers at NYU Langone Medical Center suggest that they have found a possible — and potentially surprising — root cause of the increased frequency of certain eye infections among contact lens wearers. In a study report on their work to be presented at the annual meeting of the American Society for Microbiology on May 31 in New Orleans, NYU

The phrase “work-life balance” is surprisingly controversial, sparking heated debates among dedicated employees, hard-working parents and people who fall into both camps. Is it a goal worth striving for, an unrealistic and unattainable idea, or something entirely different? In recognition of National Amazing Month, The Huffington Post spoke with Randi Zuckerberg — successful media entrepreneur, editor-in-chief of Dot Complicated, and proud mother — to find out how she thinks about and acts on the challenge

Being released this week is a new documentary from intrepid filmmaker Lucy Walker about confronting one of life’s most daunting moments. Breakthroughs in modern science allows us the ability to take a peek under our genetic “hoods” at minimal cost and with unprecedented speed. Services like 23andMe allow any consumer to explore their gene profile, which could be empowering or frightening depending on your perspective and family history. This data, when used in the clinic,

I love Michael Leunig’s cartoons, their whimsy speaks to me, and I always felt myself a Mr. Curly type, in need of a direction finding duck sometimes in the storms of life. I was therefore saddened by his recent cartoon depicting a mother running from flying needles, with anti-vaccination overtones. Leunig has always been on the “spiritual” side of any debate, however, in this case his vision has potential to cause adverse real world outcomes.

Scientists have long known that sleep boosts the brain, helping us consolidate memories and learn new things. Now, a provocative new study shows it may even have the power to help us reverse deeply rooted stereotypes against women and African-Americans — a finding which has important implications given the state of race relations in America, and the gender gap in math and science. “These biases are well-learned,” Dr. Xiaoqing Hu, a postdoctoral researcher at the

Search results The literature search identified 12,249 citations with 412 duplicates. Titles or abstracts (if available) were screened for eligibility, yielding 126 citations for full text review. Twelve studies were case reports. Twenty-nine studies were editorials or reviews. Eleven studies did not report on the rate or progression of cervical complications. Eleven studies examined patients with severe neck complaints or suspected/known cervical instabilities. Six excluded studies examined the prevalence of cervical instabilities in RA but

By Gopal Sharma KATHMANDU (Reuters) – Thousands of children affected by last month’s earthquake in Nepal returned to schools on Sunday, a working day in the Himalayan nation, five weeks after the disaster killed more than 8,600 people and destroyed many homes. Dressed informally, children clutched their parents’ hands before filing past ruins of collapsed buildings to enter tarpaulin tents and makeshift cottages that will serve as their schools until their old one is re-built.

WASHINGTON (AP) — The Obama administration says a new federal rule regulating small streams and wetlands will protect the drinking water of more than 117 million people in the country. Not so, insist Republicans. They say the rule is a massive government overreach that could even subject puddles and ditches to regulation. Sen. Shelley Moore Capito, R-W.Va., is promising to “rein in” the government through legislation or other means. It’s a threat with a familiar

BANGKOK (Reuters) – Thailand’s king was admitted to hospital on Sunday for a health check up and will stay overnight, the palace said. Examination of King Bhumibol Adulyadej, 87, showed a normal heartbeat and no respiratory infections, according to a statement from the Royal Household Bureau. Blood tests and body temperature measurement also showed no abnormalities. Bhumibol is widely revered by Thais, most of whom have only experienced his more than six decade reign. The

MOSCOW (AP) — Alarmed by a rash of suicides by cancer sufferers in Moscow, health officials are urging those unable to get access to necessary pain killers to contact the Russian Health Ministry directly. More than 10 people suffering from cancer have taken their lives in Moscow in the past four months, including a cardiologist and a psychology professor. The most recent suicide occurred last week, when a 36-year-old man hanged himself. Many of these

The phrase “work-life balance” is surprisingly controversial, sparking heated debates among dedicated employees, hard-working parents and people who fall into both camps. Is it a goal worth striving for, an unrealistic and unattainable idea, or something entirely different? In recognition of National Amazing Month, The Huffington Post spoke with Randi Zuckerberg — successful media entrepreneur, editor-in-chief of Dot Complicated, and proud mother — to find out how she thinks about and acts on the challenge

Each week HuffPost Gay Voices, in a partnership with blogger Scout, LGBT HealthLink and researcher Susana Fajardo, brings you a round up of some of the biggest LGBT wellness stories from the past seven days. For more LGBT Wellness visit our page dedicated to the topic here. 1 Doug Menuez 2 3 Shutterstock / Andrey_Popov 4 Tetra Images 5 shutterstock 6 Shutterstock / CandyBox Images

By Wendy DeChambeau, InternationalLiving.com This article comes to us courtesy of InternationalLiving.com, the world’s leading authority on how to live, work, invest, travel, and retire better overseas. Each morning Tennessee natives Bobby and Becca Vines are greeted by views of two stunning volcanoes. Small-town life in Cotacachi, Ecuador, is never dull, and the couple spends their days viewing international films, enjoying live music, and visiting with the locals. Bobby and Becca spent much of their

i Carlo Ratti of MIT designed this “supermarket of the future” exhibit. If you move a hand close to a product, a digital display lights up, providing information on origin, nutritional value and carbon footprint. Courtesy of COOP Italia hide caption itoggle caption Courtesy of COOP Italia Carlo Ratti of MIT designed this “supermarket of the future” exhibit. If you move a hand close to a product, a digital display lights up, providing information on

i Planetary Society’s LightSail experiment. Planetary Society hide caption itoggle caption Planetary Society Planetary Society’s LightSail experiment. Planetary Society The Planetary Society says it has regained contact with its LightSail satellite after fears last week that it had permanently lost touch with the tiny spacecraft launched earlier this month to lay the groundwork for testing a solar sail in Earth orbit. The private organization, headed by Bill Nye, launched LightSail on May 20 aboard an

Treating advanced melanoma patients with either a combination of the immunotherapy drugs nivolumab (Opdivo) and ipilimumab (Yervoy) or nivolumab alone significantly increases progression-free survival (PFS) over using ipilimumab alone, according to new findings from researchers at Memorial Sloan Kettering Cancer Center (MSK) simultaneously presented today at the American Society of Clinical Oncology (ASCO) annual meeting and published online in the New England Journal of Medicine (NEJM). Examining specific characteristics of each patient’s tumor has also

Study site and tissue sampling The study site is located in the French Alps (Mont Blanc massif), between 1’100 and 2’100 m above sea level. We collected a total of 170 samples from blotched (N?=?113) and non-blotched (N?=?57) snakes between 2006 and 2010. Based on their location, we grouped the samples into 12 populations (see Figure 4; in red, populations with a proportion of non-blotched individuals higher than 50%). Figure 4. Distribution and proportion of non-blotched

Review Fanny Rancière123?, Jasmine G. Lyons3?, Venurs H.Y. Loh3, Jérémie Botton124, Tamara Galloway5, Tiange Wang6, Jonathan E. Shaw3 and Dianna J. Magliano3* * Corresponding author: Dianna J Magliano [email protected] ? Equal contributors Author Affiliations 1 Inserm, U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Research Centre (CRESS), Early Origin of the Child¿s Health and Development (ORCHAD) Team, Villejuif, France 2 Univ Paris Descartes, UMR1153, Paris, France 3 Department of Clinical Diabetes and Epidemiology, Baker IDI Heart

1 Mechanical Engineering Department, University of Zabol, Zabol, Iran 2 Mechanical Engineering Department, K. N. Toosi University of Technology, Tehran, Iran For all author emails, please log on.

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You would be hard-pressed to find a person who doesn’t know about the dangers of smoking. The deadly habit can lead to a slew of health complications including heart disease and cancer. “Dancing with the Stars” pro Mark Ballas and his mother, Shirley,  made a pact to quit smoking together and are now teaming up with GlaxoSmithKline (GSK) Consumer Healthcare to share their story. Mark grew up in his mother’s homeland of England, where he

Name: Ernest PaigeAge: 29Location: El Paso, TexasHeight: 5’11”Before: 400 lbs.After: 234 lbs. What was the turning point that prompted you to lose weight? In 2011, I moved from Ohio to Los Angeles. After being there for 18 months, I saw so many people in shape and I was envious. Living in the Midwest, there’s less of an emphasis on fitness and vanity. As a result, I was too comfortable with eating whatever I wanted and

Between doctor’s appointments, childbirth classes, eating healthy and exercising, pregnancy is a busy time. Then add in all of the questions that come up about your health and your baby’s development, what’s safe and what’s not, labor, delivery and beyond, and it’s enough to make any pregnant woman want to take a nap. Take heed. There are a ton of pregnancy apps to help you stay healthy and relaxed from the minute you conceive until

Authorities in a north Indian state have filed a criminal case against Nestle India after finding dangerous levels of lead in a batch of Maggi noodles, an official said Sunday. The Food Safety and Drug Administration` (FDA) in northern Uttar Pradesh state has said high lead levels were found during routine tests in two dozen packets of instant noodles, along with flavour enhancer MSG, in March. The FDA earlier this month ordered the company to

By P.J. Huffstutter CHICAGO (Reuters) – Indiana is training 300 prisoners to kill infected chickens and banning bird shows at county fairs. Mississippi is considering road barricades and planning biosecurity measures. Iowa is trying to figure out how to deal with a mountain of dead – and reeking – chickens. Federal health experts are hopeful that the virulent bird flu that has devastated Midwestern poultry farms in recent months has reached its peak and will

According to her family, the oldest Frenchwoman alive, Eudoxie Baboul, aged 113, owes her longevity to cassava semolina. From genes to the environment, via psychology and lifestyle, a breakdown of what increases a person’s chances of living for a century. In 50 years, France could have 200,000 centenarians, or 60 times more than today according to the National Institute of Statistics and Economic Studies. For the last dozen years, scientists have been focusing on their

1 Centre for Primary Care and Public Health, Queen Mary University of London, 58 Turner Street, London E1 2AB, UK 2 Department of Primary Care Health Sciences, University of Oxford, New Radcliffe House, Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6GG, UK For all author emails, please log on.

BEIJING (AP) — Hong Kong authorities quarantined 18 fellow passengers of a South Korean man who arrived in the city infected with Middle East Respiratory Syndrome, or MERS. The Chinese city’s health authorities said Saturday the 18 are quarantined in the Lady MacLehose Holiday Village resort in a remote part of Hong Kong for two weeks. They were seated within two rows of the South Korean man, but have not showed any symptoms so far.

Seoul (AFP) – South Korea’s health minister apologised on Sunday for failing to halt an outbreak of the MERS virus, vowing “utmost efforts” to curb the disease’s spread as the number infected rose to 15. “We apologise for causing concern and anxiety among people due to… our initial judgement on the contagiousness of MERS,” Minister Moon Hyung-Pyo told reporters. Moon added this week would be a “critical period” to contain the spread of MERS, or

In August 2005, PLoS Medicine published an essay by John Ioannidis called: ‘Why most published research findings are false’ 1]. Since then, the paper has been viewed over a million times possibly because of its provocative title, but probably because of growing concerns about the reliability of scientific publications and diminishing confidence in the peer review process to deliver effective quality control. Most recently such concerns have been supported by a number of high profile

Ethics statement Mussel collection were performed under permit number RES2014/12 issued by the Department of Agriculture Forestry and Fisheries to the Department of Zoology and Entomology at Rhodes University. Genetic data DNA extraction, amplification and genotyping Mussels (adults, 4cm in shell length) were collected between February 2010 and May 2013 at six locations in southern Africa (Figure 1A and Table 1) in the middle portion of the species’ vertical distribution. Mantle tissue (20-30 mg) was dissected from

1 School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China 2 Chinese Cochrane Centre, Si Chuan University, Si Chuan, China For all author emails, please log on.

World Journal of Surgical Oncology 2015, 13:192 doi:10.1186/s12957-015-0602-x Published: 1 June 2015

This updated analysis provides the latest information on trends in mortality from childhood cancer in Japan. We found that dramatic declines in mortality occurred during 1980–2003 for boys and 1980–2001 for girls. In the last 5 years, there have been modest but statistically insignificant reductions in mortality for both sexes. The declines in childhood cancer mortality in the 1980s and 1990s are most likely due to improved survival. Early diagnosis and better therapies for childhood cancer

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Astellas Pharma Inc. (TSE: 4503) today announced that preliminary data from a Phase 1/2 trial on the safety, tolerability and efficacy of ASP2215, a selective inhibitor of FLT3/AXL, in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) were presented during an oral abstract session at the American Society of Clinical Oncology’s (ASCO) annual meeting in Chicago. ASP2215 is a receptor tyrosine kinase inhibitor of FLT3 and AXL, which are involved in the growth

By Jeff Mason and Frances Kerry WASHINGTON (Reuters) – Former Delaware Attorney General Beau Biden, son of U.S. Vice President Joe Biden, died on Saturday after battling brain cancer, the vice president said. He was 46. “The entire Biden family is saddened beyond words,” Vice President Biden said in a statement released by the White House. “We know that Beau’s spirit will live on in all of us, especially through his brave wife, Hallie, and

For more than a decade, oncologists using cytotoxic chemotherapy to treat patients with advanced metastatic castration-resistant prostate cancer (mCRPC) have relied on the sequential use of single agent taxanes such as docetaxel and cabazitaxel. For example, docetaxel is commonly used as the “first-line” therapy, while cabazitaxel is used as the “second-line” therapy. A role for combination therapy using two or more chemotherapy agents at the same time has not been well studied. This week, however,

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Despite advances in managing and curing some forms of breast cancer, women whose disease becomes metastatic have fewer effective options. A new phase 3 study in some of the most difficult-to-treat patients, women with endocrine-resistant disease, showed that the newly approved drug, palbociclib, more than doubled the time to cancer recurrence for women with hormone-receptor (HR+) positive metastatic breast cancer. The results will be presented at the 2015 annual American Society of Clinical Oncology (ASCO,

An intervention known as remote ischemic preconditioning (RIPC) significantly reduced the occurrence of acute kidney injury (AKI) in cardiac surgery patients and confirmed that post-operative elevations of two kidney biomarkers act as an alarm for risk of AKI, according to a study published online today in the Journal of the American Medical Association. Investigators in the study used Astute Medical, Inc.’s NephroCheck® Test to obtain measurements of the two biomarkers, tissue inhibitor of metalloproteinase 2

Eisai Inc. announced today the results of its Phase 3 trial (Study 309), which showed that eribulin met the study’s primary endpoint evaluating overall survival in patients who had advanced leiomyosarcoma (LMS) or adipocytic sarcoma (ADI), two types of advanced soft tissue sarcoma. These data will be presented at the 51st Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago as part of the ASCO press conference on Saturday, May 30, and

GenomeDx Biosciences today announced that data presented at the 2015 American Society of Clinical Oncology Annual Meeting demonstrate that the Decipher® Prostate Cancer Classifier is a significant predictor of metastasis in patients treated with postoperative salvage radiation therapy. Importantly, patients with a low Decipher score had excellent outcomes overall, independent of whether they received early or late salvage radiation, and with or without concurrent hormone therapy. In contrast, patients with a high Decipher score had

Electronic cigarettes, hookahs and waterpipes are just as bad for you as traditional cigarettes, warns the European Society of Cardiology. “Smoking of all types is still, without any competition, the strongest risk factor for cardiovascular disease. It beats everything,” says ESC prevention spokesperson Dr. Joep Perk on the occasion of World No Tobacco Day. “There has been a lot of research over the past 2-3 years which makes us very clear that all tobacco use,

(Reuters) – A man being monitored for Ebola at the University of Kansas Hospital has tested negative for the deadly disease, the hospital said on Saturday. The man had returned from the West African nation of Sierra Leone and developed a fever. The hospital said in a statement that the patient had tested positive for malaria. Tests from a regional lab in Nebraska showed no Ebola virus, it said. Hospital officials had said on Friday

By Bill Berkrot (Reuters) – A Merck Co drug that helps the immune system fight cancer was about twice as effective as the current standard therapy for patients with recurrent or advanced head and neck cancers, according to study data released on Friday. A quarter of the 132 patients who received the drug, Keytruda (pembrolizumab), saw their tumors shrink by at least 30 percent. Fifty-six percent of patients experienced at least some tumor shrinkage in

By Jeff Mason and Frances Kerry WASHINGTON (Reuters) – Former Delaware Attorney General Beau Biden, son of U.S. Vice President Joe Biden, died on Saturday after battling brain cancer, the vice president said. He was 46. “The entire Biden family is saddened beyond words,” Vice President Biden said in a statement released by the White House. “We know that Beau’s spirit will live on in all of us, especially through his brave wife, Hallie, and

By Megha Rajagopalan BEIJING (Reuters) – Beijing will ban smoking in restaurants, offices and on public transport from Monday, part of unprecedented new curbs welcomed by anti-tobacco advocates, though how they will be enforced remains to be seen. Health activists have pushed for years for stronger restrictions on smoking in China, the world’s largest tobacco consumer, which is considering further anti-smoking curbs nationwide. Under the rules, anyone in China’s capital who violates the bans, which

i In this episode of NPR’s series Inside Alzheimer’s, we hear from Greg O’Brien about his struggle to deal with the hallucinations that are an increasing part of his illness. O’Brien, a longtime journalist in Cape Cod, was diagnosed with early-onset Alzheimer’s disease in 2009. Greg O’Brien sees things that he knows aren’t there, and these visual disturbances are becoming more frequent. That’s not uncommon; up to 50 percent of people who have Alzheimer’s disease

i Dwayne “The Rock” Johnson and Carla Gugino star in the action thriller San Andreas. Jasin Boland /Courtesy of Warner Bros. Pictures hide caption itoggle caption Jasin Boland /Courtesy of Warner Bros. Pictures Dwayne “The Rock” Johnson and Carla Gugino star in the action thriller San Andreas. Jasin Boland /Courtesy of Warner Bros. Pictures The new movie San Andreas, starring Dwayne Johnson (better known as The Rock), is about a California earthquake so powerful that

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IMAGE: This is Paul Corn, M.D., Ph.D. view more Credit: MD Anderson Cancer Center For more than a decade, oncologists using cytotoxic chemotherapy to treat patients with advanced metastatic castration-resistant prostate cancer (mCRPC) have relied on the sequential use of single agent taxanes such as docetaxel and cabazitaxel. For example, docetaxel is commonly used as the “first-line” therapy, while cabazitaxel is used as the “second-line” therapy. A role for combination therapy using two or more chemotherapy

Forget the basic bikini wax. The Brazilian wax— which entails removing all of the hair down there (even between the cheeks!)— has become as standard a rite of summer for some women as spray tans and pedicures.   In fact, many of us wouldn’t dare to slip into a swimsuit before enduring the 30 or so minutes of physical torture it takes to achieve the sexy, sleek, “clean” look and feel that a Brazilian offers.

i The sun sets along 42nd Street in Manhattan in 2013 during a semi-annual phenomenon known as “Manhattanhenge,” when the sun aligns perfectly with the city’s transit grid. John Minchillo/AP hide caption itoggle caption John Minchillo/AP The sun sets along 42nd Street in Manhattan in 2013 during a semi-annual phenomenon known as “Manhattanhenge,” when the sun aligns perfectly with the city’s transit grid. John Minchillo/AP It’s a semi-annual alignment of sun and skyscrapers in downtown

CTI BioPharma Corp. (CTI BioPharma) (NASDAQ and MTA: CTIC) and Baxter International’s Bioscience business (NYSE: BAX) today announced data from PERSIST-1 – a randomized Phase 3 registration-directed trial examining pacritinib for the treatment of myelofibrosis – in a late-breaking oral session at the 51st Annual Meeting of the American Society of Clinical Oncology (ASCO), May 29-June 2, 2015 in Chicago, Ill. Pacritinib is an investigational oral multikinase inhibitor with specificity for JAK2 and FLT3. Data

ESMO, the European Society for Medical Oncology, has announced today the publication of the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS), a tool to assist oncology clinicians in evaluating the most effective anti-cancer medicines for their patients. “While it is known that the value of any new treatment is determined by the magnitude of its clinical benefit against its cost, to date there has not been a standard tool for grading such magnitude,” says Nathan

Because of the significant benefit found in combining the targeted drug ibrutinib with standard chemotherapy for relapsed chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), an interim analysis has closed the international HELIOS phase III clinical trial. Led by Mayo Clinic, researchers found that ibrutinib and chemotherapy (bendamustine and rituximab, known as BR) reduced the risk of death or cancer progression by almost 80 percent in patients with previously treated CLL or SLL, compared

Use of the targeted agent pacritinib significantly reduced the symptoms and burden of advanced myelofibrosis in patients, says a Mayo Clinic researcher who co-led PERSIST-1, the worldwide phase III clinical trial that tested the therapy. Specifically, pacritinib substantially reduced severe enlargement of the spleen, a typical feature of advanced myelofibrosis, in more than 20 percent of patients and alleviated debilitating side effects in more than 46 percent. Investigators further found that pacritinib could be used

By Bill Berkrot (Reuters) – An experimental biotech drug being developed by Johnson Johnson may offer hope to multiple myeloma patients who have run out of options, according to data from a midstage study released at a cancer meeting on Saturday. JJ plans to use the Phase II study to seek U.S. and European approval of its antibody daratumumab to treat the blood cancer. The drug received breakthrough designation from the U.S. Food and Drug

CHICAGO (Reuters) – A drug made by Japan’s Eisai Co that was originally derived from sea sponges helped extend lives of patients with soft-tissue cancers known as sarcomas by two months, a significant advance for these rare cancers with few treatment options, Belgian researchers said on Saturday. The researchers studied the drug, known as eribulin, in 452 patients with two forms of sarcomas – leiomyosarcoma, which starts in smooth muscles, and adipocytic sarcoma, which starts

LOS ANGELES (AP) — The worst day of Aaron Baker’s life wasn’t when the then-20-year-old professional motocross racer crashed his bike one spring day in 1999, flew over the handlebars and hit the ground head-first, paralyzing him from the next down. No, the worst day came a year later when Baker’s physical therapy ended. That was when his therapists, marveling that he could actually stand on his own again and move his arms some, cautioned

Promising advances in research could mean longer, healthier lives for women with breast cancer, the number one cancer in women worldwide, experts said Saturday at a major US cancer conference. A new targeted therapy that appears to double the amount of time cancer can be held in check, a drug that offers more women a chance at healthy lives post-diagnosis and a surgical option to remove extra tissue in order to reduce the likelihood of

When we’re slipping on anxiety’s slopes, it’s usually not pretty. We rant. We rave. We make blanket statements on the condition of our lives. When under pressure, inaccurate self-judgments are likely to creep in. We forget to factor in that we’re overworked, tired or just plain depleted. We lose sight that we’re resilient, and quite capable of coming up for air and regrouping once we’ve regained our footing. Psychologists call the tendency to zoom in

Were you that kid who was constantly getting called out for daydreaming? “Pay attention.” “Stop daydreaming.” “Is anybody in there?” Me too. But the funny thing is I never stopped. Some people feel daydreaming is all about wasting time, zoning out, or simply not wanting to be present for whatever is happening in the now. But that’s not necessarily the case. Research shows that more than one third of our waking hours is spent daydreaming.

When people think about fitness and getting in shape, the most common focuses are usually exercise and diet. We know that burning calories and eating right contribute to a better body, but what about rest? Mounting evidence shows that sleep is a vital component of fitness as well, important not only for energy, but also for keeping muscles healthy and hormones balanced. Research from Stanford found improved athletic performance when their basketball team slept more,

1 Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2 Department of Environmental Health Engineering, School of Public Health, Hormozgan University of Medical Sciences, Bandar- Abbas, Iran 3 Center for Solid Waste Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran 4 National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran For all author emails, please log on.

A collaborative team of researchers led by Alex A. Adjei, MD, PhD, FACP, of Roswell Park Cancer Institute (RPCI) will share results from the first clinical study of the anticancer effects of the novel agent entolimod at the American Society of Clinical Oncology (ASCO) 51st Annual Meeting in Chicago. Their findings confirm preclinical evidence that the agent, which is derived from salmonella flagellin, is worthy of further investigation as treatment for some of the most

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As the rate of opioid abuse soars to new levels, growing recognition of the problem is garnering unprecedented media attention—as well as motivating innovative new approaches to better treatment. For example, generic Vicodin (hydrocodone acetaminophen) ranked as the drug most widely prescribed to Medicare beneficiaries in 2013, according to a new article in The Wall Street Journal. This illustrates how comfortable many doctors have become reaching for this powerful painkiller for primary care, despite its

Data from the international, multi-center, open-label, two-part, single-arm Phase 2 MMY2002 (SIRIUS) trial show treatment with single-agent daratumumab – an investigational, human anti-CD38 monoclonal antibody – achieved an overall response rate (ORR) of 29.2 percent (95% CI, 20.8-38.9), as assessed by an independent review committee, in heavily pre-treated patients with multiple myeloma. The ORR was consistent among the pre-specified subgroups based on age, prior lines of therapy, type of myeloma and baseline renal function. Median