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In a small pilot study, some young women looking to lose weight on a low-calorie keto diet got an unexpected benefit: Their acne began to clear up. “These findings represent an opportunity to control a skin disease that affects most teenagers and many adults at some point in their lifetimes, causing distress, embarrassment, anxiety and Read More
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The menthyl esters of valine (MV) and isoleucine (MI) are multi-faceted molecules with enhanced anti-inflammatory and anti-obesity activities. The discovery and development of such molecules can result in newer classes of therapeutic drugs to treat a wide range of metabolic disorders. Credit: Gen-ichiro Arimura from Tokyo University of Science Modified derivatives of natural products have Read More
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Credit: Mayo Clinic Chemotherapy is usually the first treatment doctors try to treat lymphoma, including the two most common forms: non-Hodgkin and Hodgkin. But alternatives to chemotherapy are developing, as first-line treatments and as backup options, explains Stephen Ansell, M.D., Ph.D., hematology chair and hematologic oncologist at the Mayo Clinic Comprehensive Cancer Center. Lymphoma is Read More
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Credit: Karolina Grabowska from Pexels Navels, belly buttons, innies or outies … whatever term you use, your umbilicus may have plenty to tell you about the state of your health. For some, they are the thing of nightmares—omphalophobia (the fear of belly buttons) is a real condition. For others, they are a fashion accessory to Read More
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Direct contact transmission, weight loss, and survival for ferrets infected with A/mink (H5N1). Four donor ferrets were inoculated with A/mink (H5N1) and 24?h later each donor was paired with a contact in the same cage. Nasal wash samples were collected every other day for 13 days, and weight loss and clinical signs were monitored. A, Read More
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With rates of depression rising among young people on university campuses, a team of SMU researchers found that combining two different therapeutic approaches demonstrated effectiveness in improving students’ overall mental health. Their findings show that students receiving behavioral activation (BA) therapy augmented with savoring (S) experienced improvements in positive and negative mood. Behavioral activation is Read More
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Prediction models generated by machine learning are being increasingly used in medicine to identify risk factors and possible outcomes, especially for total joint replacements of knees and hips—although researchers warn that machine-generated predictions are currently being drawn from a limited data pool. “Machine learning has great potential for processing ‘big data’ and has proved its Read More
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As the U.S. Food and Drug Administration explores front-of-package nutrition labeling to help American consumers make healthier eating choices, a new University of Massachusetts Amherst study finds that a food labeling system introduced by the French government in 2017 resulted in healthier products. The study of Nutri-Score, a voluntary labeling system that assigns a simple Read More
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Jeremy Luban, MD. Credit: University of Massachusetts Medical School The presence of the highly pathogenic avian influenza (H5N1) virus in dairy cattle and milk has put public health experts on high alert. In a recent interview for UMass Chan News, physician-scientist Jeremy Luban, MD, the David J. Freelander Memorial Professor in AIDS Research and professor Read More
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Using genetically engineered mice expressing a specific variant of HLA, researchers uncover the instrumental role of this protein in the development of drug eruptions. They found that when HLA binds to an antiviral drug, abacavir, it can lead to the formation of defective proteins, which trigger a stress response in the endoplasmic reticulum, ultimately cascading Read More
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Challenges encountered and solutions developed during the iterative construction of the hybrid-virtual home visits. Credit: Journal of General Internal Medicine (2024). DOI: 10.1007/s11606-023-08460-5 In a new study, a team developed and successfully tested a hybrid-virtual home visit model that provides care to veterans who do not live close to a VA health care facility. The Read More
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Digital twins of athletes allow athletes and coaches to evaluate performance and trial technique changes. It’s an open secret that the countries that win the most medals in the Olympics and Paralympics combine talent and technology. Athletes are preparing for the next three Olympics and Paralympics in Paris in 2024, Los Angeles in 2028, and Read More
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The effects of optogenetic inhibition on WM task performance. a, The experimental set-up. b, The delayed-association WM task trial types; licking was assessed during the 3?s choice period, with early- and late-delays periods noted. c, Learning progress across eight sessions, measured on the basis of the percentage of correct responses. d, Learning session example, with Read More
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It’s no secret that the Mediterranean diet is good for your health. Already recommended to reduce the risks of bowel cancer, heart disease, and dementia, new research from the University of South Australia published in the journal Nutrients shows that the Mediterranean diet can also reduce symptoms of stress and anxiety. Conducted in partnership with Read More
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Credit: Cell (2024). DOI: 10.1016/j.cell.2024.04.025 Immunotherapy has revolutionized the way we treat cancer in recent years. Instead of targeting the tumor itself, immunotherapies work by directing patients’ immune systems to attack their tumors more effectively. This has been especially effective in improving outcomes for certain difficult-to-treat cancers. Still, fewer than half of all cancer patients Read More
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Sprint interval exercises can stimulate beneficial physiological and metabolic responses via the activation of muscles and increased oxygen uptake in tissues. Credit: Medicine & Science in Sports & Exercise (2024). DOI: 10.1249/MSS.0000000000003420 Physical activities like jogging, walking, cycling, and sprinting are activities known to engage the musculoskeletal system and result in the utilization of energy. Read More
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In the international CONVINCE trial, presented today (15 May 2024) at the European Stroke Organization Conference (ESOC 2024), anti-inflammatory treatment with long-term colchicine did not reduce rates of recurrent stroke and cardiovascular events in patients with non-cardioembolic stroke in the primary intention-to-treat analysis. Reduced event rates in secondary analyses, and in the subgroup of patients Read More
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A compound called K11777 prevents body cells from splitting the viral capsid and thus helping the virus out of its capsid. This means that infection is no longer possible. Credit: Ruhr-Universitaet-Bochum At present, there is no specific active substance against hepatitis E. As the disease kills 70,000 people every year, researchers are actively searching for Read More
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Credit: Med (2024). DOI: 10.1016/j.medj.2024.02.010 Spinal muscular atrophy (SMA) is a terrible disease in which a genetic mutation causes certain nerves responsible for sending signals to muscles to degenerate. This leads to muscles wasting away, and many patients have died a painful death due to this rare condition. Genetic treatments have only been available for Read More
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Graphical abstract. Credit: Journal of Internal Medicine (2024). DOI: 10.1111/joim.13773 A study by Rutgers Health experts of more than 31 million hospital records shows that infertility treatment patients were twice as likely as those who conceived naturally to be hospitalized with heart disease in the year after delivery. The work is published in the Journal Read More
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The figures depict images of invasive ductal carcinoma, mucinous carcinoma, and papillary carcinoma, respectively. Despite the variations in tissue structures among different tumor types, the activated regions of the model corresponded to the areas of yellow malignant cell aggregation. Scale bar = 100?µm. Credit: Science China Press Rapid and accurate intraoperative diagnosis is critical for Read More
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Schematic of neutrophil PARP-1-ALOX5-mediated MMP-9 in lung cancer. Infiltrated neutrophils are increased in lung cancer tissues and negatively correlated with the prognosis of patients. After neutrophils are exposed to lung cancer cells, PARP-1 interacts with ALOX5 and enhances protein stabilization through PARylation of ALOX5. Increasing ALOX5 metabolites promotes MMP-9 production via activation of ERK and Read More
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Considered a best practice at academic medical centers, tumor boards bring together multidisciplinary teams of experts to determine the optimal course of treatment for patients with cancer. In the wake of the COVID-19 pandemic, medical and surgical oncologists, radiologists, pathologists, and other relevant specialists often come together using online platforms. An exhaustive prospective analysis published Read More
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A nationwide assessment of how nonprofit hospitals are addressing housing-related needs in their communities appears in the latest issue of Medical Care. “Approximately 60% of hospitals in the United States are 501(c)(3) nonprofit organizations and are legally required to address substantial health needs in their communities as a condition for tax exemption,” explain Berkeley Franz, Read More
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Behavioral analyses in zebrafish with disrupted dopaminergic signaling during development. Credit: The American Journal of Pathology (2024). DOI: 10.1016/j.ajpath.2024.02.014 Recent evidence suggests that dopamine plays a crucial role in neural development. In a novel study, investigators demonstrated the link between disrupted developmental dopamine signaling and autism spectrum disorder (ASD). Their findings underscore the importance of Read More
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A new University of Cincinnati study provides more insight into how few patients have severe ischemic strokes compared to the total stroke patient population in the region. UC’s Yasmin Aziz, MD, will present a poster on the team’s findings during the European Stroke Organisation Conference (ESOC) this week in Basel, Switzerland. Ischemic strokes, the most Read More
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Cyclin D1 protein expression by immunohistochemistry in histological sections. Credit: Oncotarget (2024). DOI: 10.18632/oncotarget.28584 A new research paper titled “Cyclin D1 expression in penile cancer” has been published in Oncotarget. In this new study, researchers analyzed the expression profile of cyclin D1 in patients with penile cancer (PC), and to determine possible correlations with clinical Read More
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A new guideline has been issued to help neurologists and other clinicians determine the best antiseizure medications for people with epilepsy who may become pregnant. The guideline is published in the May 15, 2024, online issue of Neurology and was developed through a collaboration between the American Academy of Neurology (AAN), the American Epilepsy Society Read More
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A new study has advanced how heart failure is detected in women—meaning more female patients can be diagnosed and at an earlier stage. Researchers led by teams from the Universities of East Anglia (UEA), Sheffield and Leeds, have been able to fine-tune how magnetic resonance imaging (MRI) is used to detect heart failure in women’s Read More
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Lead by a team of researchers at University Hospitals (UH) Connor Whole Health, a new study finds that patients seeking outpatient integrative health and medicine (IHM) care experience clinically meaningful reductions in symptoms of pain, anxiety, and stress after just one treatment. The research is published in the journal Global Advances in Integrative Medicine and Read More
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